Acetylcholinesterase and its Kinetics in the Diagnosis of Myocardial Infarction

Myocardial Infarction (MI) has been diagnosed on the basis of enzyme assay such as CK-MB, SGOT, LDH and troponin I & troponin T in addition to clinical findings, ECG changes and Echocardiographic changes. In 1 the present study another enzyme AChE has been taken to estimate the damage of myocardium because heart is richly innervated by cholinergic nerves. Along with the study of AChE enzyme kinetics will help to ascertain the salvage of myocardium, which will affect the contractility of myocardium. The CK-MB & SGOT levels were found to be increased in correlation with STelevation in ECG tracings. In the present study the Km was increased from -3 -3 2.76 x 10 M to 4.5 x 10 M. However, the AChE activity was inhibited as the activity is inversely proportion to Km. Madhavi Gaur, Rajeev Gupta* and Santosh Kumar** Sant Hirdaram Girls College, Hirdaram Nagar, Bhopal (M.P.) * Associate Professor, Department of Cardiology, Gandhi Medical College, Bhopal (M.P.) ** Former Vice Chancellor, Dr. H.S. Gour University, Sagar (M.P.)